Buccafusco_1980_Psychopharmacology.(Berl)_67_249

Reference

Title : Opposing influences on behavior mediated by muscarinic and nicotinic receptors in the rat posterior hypothalamic nucleus - Buccafusco_1980_Psychopharmacology.(Berl)_67_249
Author(s) : Buccafusco JJ , Brezenoff HE
Ref : Psychopharmacology (Berl) , 67 :249 , 1980
Abstract :

Microinjection of carbachol into the posterior hypothalamic nucleus (PHN) of freely moving rats evoked marked behavioral changes characterized by an escape reaction. This response was quantitated by measuring locomotor activity. In contrast, cholinergic stimulation of the PHN with neostigmine produced sedation and inactivity. Local pretreatment with the nicotinic receptor blocking agent mecamylamine blocked the excitatory effects of carbachol while the muscarinic antagonist atropine abolished the inhibitory effect of neostigmine on motor activity. It is concluded that behavioral changes evoked through cholinergic stimulation of the PHN may be mediated by a muscarinic system which controls sedation and a nicotinic pathway which mediates arousal.

PubMedSearch : Buccafusco_1980_Psychopharmacology.(Berl)_67_249
PubMedID: 6770404

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Citations formats

Buccafusco JJ, Brezenoff HE (1980)
Opposing influences on behavior mediated by muscarinic and nicotinic receptors in the rat posterior hypothalamic nucleus
Psychopharmacology (Berl) 67 :249

Buccafusco JJ, Brezenoff HE (1980)
Psychopharmacology (Berl) 67 :249