| Title : Adrenergic agonists protect against soman, an irreversible acetylcholinesterase inhibitor - Buccafusco_1987_Toxicol.Lett_38_67 |
| Author(s) : Buccafusco JJ , Aronstam RS |
| Ref : Toxicol Lett , 38 :67 , 1987 |
|
Abstract :
Adrenergic drugs from several chemical classes were compared with clonidine as protectants against soman toxicity. All agents tested produced some degree of protection. Alpha-adrenergic agonists such as methyldopa, xylazine and clonidine were among the most effective drugs, while a dopaminergic agonist (bromocriptine) and beta-receptor antagonist (pindolol) were the least effective. Potency for protection was related to affinity for alpha-adrenergic binding sites labelled with [3H]clonidine. Atropine acted synergistically with adrenergic agonists to potentiate protection. |
| PubMedSearch : Buccafusco_1987_Toxicol.Lett_38_67 |
| PubMedID: 2820088 |
Buccafusco JJ, Aronstam RS (1987)
Adrenergic agonists protect against soman, an irreversible acetylcholinesterase inhibitor
Toxicol Lett
38 :67
Buccafusco JJ, Aronstam RS (1987)
Toxicol Lett
38 :67