| Title : Synthesis of alpha, beta-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: Characterization, molecular modeling, QSAR studies and effect against amyloid beta-induced cytotoxicity - Bukhari_2014_Eur.J.Med.Chem_83C_355 |
| Author(s) : Bukhari SN , Jantan I , Masand VH , Mahajan DT , Sher M , Naeem-Ul-Hassan M , Amjad MW |
| Ref : Eur Journal of Medicinal Chemistry , 83C :355 , 2014 |
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Abstract :
A series of novel carbonyl compounds was synthesized by a simple, eco-friendly and efficient method. These compounds were screened for anti-oxidant activity, in vitro cytotoxicity and for inhibitory activity for acetylcholinesterase and butyrylcholinesterase. The effect of these compounds against amyloid beta-induced cytotoxicity was also investigated. Among them, compound 14 exhibited strong free radical scavenging activity (18.39 muM) while six compounds (1, 3, 4, 13, 14, and 19) were found to be the most protective against Abeta-induced neuronal cell death in PC12 cells. Compounds 4 and 14, containing N-methyl-4-piperidone linker, showed high acetylcholinesterase inhibitory activity as compared to reference drug donepezil. Molecular docking and QSAR (Quantitative Structure-Activity Relationship) studies were also carried out to determine the structural features that are responsible for the acetylcholinesterase and butyrylcholinesterase inhibitory activity. |
| PubMedSearch : Bukhari_2014_Eur.J.Med.Chem_83C_355 |
| PubMedID: 24980117 |
Bukhari SN, Jantan I, Masand VH, Mahajan DT, Sher M, Naeem-Ul-Hassan M, Amjad MW (2014)
Synthesis of alpha, beta-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: Characterization, molecular modeling, QSAR studies and effect against amyloid beta-induced cytotoxicity
Eur Journal of Medicinal Chemistry
83C :355
Bukhari SN, Jantan I, Masand VH, Mahajan DT, Sher M, Naeem-Ul-Hassan M, Amjad MW (2014)
Eur Journal of Medicinal Chemistry
83C :355