| Title : Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments - Butov_2015_Chem.Heterocycl.Comp_50_171 |
| Author(s) : Butov GM , Burmistrov VV , Dalinger IL , Vatsadze IA , Shkineva TK , Danilov DV |
| Ref : Chem Heterocycl Comp , 50 :1719 , 2015 |
|
Abstract :
A series of 1,3-disubstituted and 1,3,3-trisubstituted isoxazolyl- and adamantyl-functionalized ureas was synthesized. The resulting compounds are potent inhibitors of soluble epoxide hydrolase. The compounds were obtained in high yields under mild conditions. Water solubility of the synthesized ureas was found to exceed significantly that of known analogs |
| PubMedSearch : Butov_2015_Chem.Heterocycl.Comp_50_171 |
| PubMedID: |
| Inhibitor | CHEMBL3633668 |
Butov GM, Burmistrov VV, Dalinger IL, Vatsadze IA, Shkineva TK, Danilov DV (2015)
Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments
Chem Heterocycl Comp
50 :1719
Butov GM, Burmistrov VV, Dalinger IL, Vatsadze IA, Shkineva TK, Danilov DV (2015)
Chem Heterocycl Comp
50 :1719