| Title : Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans by GC-MS and their cholinesterase activity - Cahlikova_2011_Nat.Prod.Commun_6_603 |
| Author(s) : Cahlikova L , Macakova K , Zavadil S , Jiros P , Opletal L , Urbanova K , Jahodar L |
| Ref : Nat Prod Commun , 6 :603 , 2011 |
|
Abstract :
The underivatized alkaloid mixture extracted from the bulbs of Chlidanthus fragrans Herb. was investigated by capillary GC/MS for the first time. Fifteen known Amaryllidaceae alkaloids of five structure types were identified. The main alkaloids were tazzetine (9, tazettine-type), chlidanthine (2, galanthamine-type), belladine (8, belladine-type) and lycorine (12, lycorine-type). The alkaloid extract from the bulbs showed promising human blood acetylcholinesterase (IC50 = 20.1 +/- 2.9 microg/mL) and human plasma butyrylcholinesterase (IC50 = 136.8 +/- 6.9 microg/mL) inhibitory activity. |
| PubMedSearch : Cahlikova_2011_Nat.Prod.Commun_6_603 |
| PubMedID: 21615016 |
Cahlikova L, Macakova K, Zavadil S, Jiros P, Opletal L, Urbanova K, Jahodar L (2011)
Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans by GC-MS and their cholinesterase activity
Nat Prod Commun
6 :603
Cahlikova L, Macakova K, Zavadil S, Jiros P, Opletal L, Urbanova K, Jahodar L (2011)
Nat Prod Commun
6 :603