Cai_2016_PLoS.One_11_e0162727

Reference

Title : Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population - Cai_2016_PLoS.One_11_e0162727
Author(s) : Cai G , Zhang B , Ma C , Shi G , Weng W , Xue S
Ref : PLoS ONE , 11 :e0162727 , 2016
Abstract :

OBJECTIVE: The aim of the present study was to assess the association between the 2037T/C and 2237G/A polymorphisms in the EL gene and the risk of CAD and lipid levels in a Chinese population.
METHODS: A case-control study including 706 patients with CAD and 315 controls was performed. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to identify the genotypes.
RESULTS: The EL 2037 T/C polymorphism was associated with CAD risk and HDL-C levels. No significant differences were found between the EL 2237 G/A genotypes and CAD risk and lipid levels in the whole population. However, carriers of the 2237 A allele had higher Apo A1 levels than those with the 2237 GG genotype and in the CAD subgroup (P = 0.044). The CAD cases have a significantly lower frequency of the C-G haplotypes than the controls, and the T-A haplotype was significantly more common in the CAD patients than in the controls.
CONCLUSIONS: Our study concluded that the EL 2037 T/C polymorphism was associated with CAD risk and HDL-C levels, and that the C allele might be a protective factor against CAD in the Chinese Han population. In addition, the EL 2237 A allele might be associated with an increased Apo A1 level in CAD subjects.

PubMedSearch : Cai_2016_PLoS.One_11_e0162727
PubMedID: 27612170

Related information

Citations formats

Cai G, Zhang B, Ma C, Shi G, Weng W, Xue S (2016)
Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population
PLoS ONE 11 :e0162727

Cai G, Zhang B, Ma C, Shi G, Weng W, Xue S (2016)
PLoS ONE 11 :e0162727