Cai_2025_Eur.J.Pharmacol__177697

Alzheimer's disease (AD) is a highly prevalent and severely harmful neurodegenerative disease. Currently, the main drugs for AD are cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists. However, their therapeutic effect is unsatisfactory, highlighting the urgent need for a new treatment strategy for AD. Cell senescence (CS) is a complex stress response. Recently, an increasing number of studies have indicated that CS is a crucial factor in AD pathogenesis. CS can be used as a potential drug target for AD treatment. However, the specific mechanism of CS in AD remains unclear. This article reviews AD pathogenesis, the mechanisms associated with CS in AD, and the CS-based therapeutic drugs for AD including chemical agents and traditional Chinese medicine. Based on this, this review also summarized the clinical feasibility and challenges of CS-based therapies and aims to provide novel insights for developing effective therapeutic strategies against AD. This review serves as a reference for clarifying the relationship between CS and AD, providing new insights into the clinical treatment of AD.