Carageorgiou_2008_Neuropsychiatr.Dis.Treat_4_687

Reference

Title : The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na, K)-, Mg-ATPase activities, antioxidant status, and learning performance of aged rats - Carageorgiou_2008_Neuropsychiatr.Dis.Treat_4_687
Author(s) : Carageorgiou H , Sideris AC , Messari I , Liakou CI , Tsakiris S
Ref : Neuropsychiatr Dis Treat , 4 :687 , 2008
Abstract :

UNLABELLED: We investigated the effects of rivastigmine (a cholinesterase inhibitor) and selegiline ((-)deprenyl, an irreversible inhibitor of monoamineoxidase-B), alone and in combination, on brain acetylcholinesterase (AChE), (Na(+), K(+))-, Mg(2+)-ATPase activities, total antioxidant status (TAS), and learning performance, after long-term drug administration in aged male rats. The possible relationship between the biochemical and behavioral parameters was evaluated.
METHODS: Aged rats were treated (for 36 days) with rivastigmine (0.3 mg/kg rat/day ip), selegiline (0.25 mg/kg rat/day im), rivastigmine plus selegiline in the same doses and way of administration as separately. Aged and adult control groups received NaCl 0.9% 0.5 ml ip.
RESULTS: TAS was lower in aged than in adult rats, rivastigmine alone does not affect TAS, decreases AChE activity, increases (Na(+), K(+))-ATPase and Mg(2+)-ATPase activity of aged rat brain and improves cognitive performance. Selegiline alone decreases free radical production and increases AChE activity and (Na(+), K(+))-ATPase activity, improving cognitive performance as well. In the combination: rivastigmine seems to cancel selegiline action on TAS and AChE activity, while it has additive effect on (Na(+), K(+))-ATPase activity. In the case of Mg(2+)-ATPase selegiline appears to attenuate rivastigmine activity. No statistically significant difference was observed in the cognitive performance.
CONCLUSION: Reduced TAS, AChE activity and learning performance was observed in old rats. Both rivastigmine and selesiline alone improved performance, although they influenced the biochemical parameters in a different way. The combination of the two drugs did not affect learning performance.

PubMedSearch : Carageorgiou_2008_Neuropsychiatr.Dis.Treat_4_687
PubMedID: 19043511

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Citations formats

Carageorgiou H, Sideris AC, Messari I, Liakou CI, Tsakiris S (2008)
The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na, K)-, Mg-ATPase activities, antioxidant status, and learning performance of aged rats
Neuropsychiatr Dis Treat 4 :687

Carageorgiou H, Sideris AC, Messari I, Liakou CI, Tsakiris S (2008)
Neuropsychiatr Dis Treat 4 :687