Title : Antibodies to beta-bungarotoxin and its phospholipase inactive derivative - Caratsch_1982_Proc.R.Soc.Lond.B.Biol.Sci_215_365 |
Author(s) : Caratsch CG , Maranda B , Miledi R , Strong PN |
Ref : Proc R Soc Lond B Biol Sci , 215 :365 , 1982 |
Abstract :
Antisera were raised against the presynaptic neurotoxin beta-bungarotoxin and against its phospholipase-inactive derivative, modified by reaction with p-bromophenacyl bromide. The cross-reactivity of the antisera to other phospholipase A2 enzymes and polypeptide neurotoxins was examined. The antisera inhibited both the neurotoxic effects of beta-bungarotoxin at the frog motor endplate and the enzymatic activity of the toxin on model phospholipid membranes, although it is unlikely that the catalytic active centre is the locus of any major determinant. |
PubMedSearch : Caratsch_1982_Proc.R.Soc.Lond.B.Biol.Sci_215_365 |
PubMedID: 6182570 |
Caratsch CG, Maranda B, Miledi R, Strong PN (1982)
Antibodies to beta-bungarotoxin and its phospholipase inactive derivative
Proc R Soc Lond B Biol Sci
215 :365
Caratsch CG, Maranda B, Miledi R, Strong PN (1982)
Proc R Soc Lond B Biol Sci
215 :365