| Title : Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease - Cardoso-Lopes_2010_Molecules_15_9205 |
| Author(s) : Cardoso-Lopes EM , Maier JA , da Silva MR , Regasini LO , Simote SY , Lopes NP , Pirani JR , Bolzani Vda S , Young MC |
| Ref : Molecules , 15 :9205 , 2010 |
|
Abstract :
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(5)(0) = 2.5 mM), similar to that of the reference compound galanthamine (IC(5)(0) = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity. |
| PubMedSearch : Cardoso-Lopes_2010_Molecules_15_9205 |
| PubMedID: 21160449 |
Cardoso-Lopes EM, Maier JA, da Silva MR, Regasini LO, Simote SY, Lopes NP, Pirani JR, Bolzani Vda S, Young MC (2010)
Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease
Molecules
15 :9205
Cardoso-Lopes EM, Maier JA, da Silva MR, Regasini LO, Simote SY, Lopes NP, Pirani JR, Bolzani Vda S, Young MC (2010)
Molecules
15 :9205