Title : Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor - Carlson_2003_Psychopharmacology.(Berl)_165_229 |
Author(s) : Carlson BB , Wisniecki A , Salamone JD |
Ref : Psychopharmacology (Berl) , 165 :229 , 2003 |
Abstract :
RATIONALE: Atypical antipsychotics such as clozapine and olanzapine have a low liability for producing motor side effects. In addition to being D2 antagonists, these drugs have a complex binding profile that includes affinity for muscarinic, alpha, H1, and various serotonin receptors. Previous work in rats has shown that atypical antipsychotics suppress tremulous jaw movements induced by the anticholinesterase tacrine in rats. Cholinomimetic-induced jaw movements are a putative model of parkinsonian tremor, and the ability of antipsychotic drugs to suppress these movements in rats is correlated with motor side-effect liability in humans. OBJECTIVE: The present work was undertaken to study the role of central serotonin receptors in the generation of cholinomimetic-induced jaw movements. |
PubMedSearch : Carlson_2003_Psychopharmacology.(Berl)_165_229 |
PubMedID: 12420151 |
Carlson BB, Wisniecki A, Salamone JD (2003)
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor
Psychopharmacology (Berl)
165 :229
Carlson BB, Wisniecki A, Salamone JD (2003)
Psychopharmacology (Berl)
165 :229