Cartuche_2022_Plants.(Basel)_11_

The present study aimed to determine the chemical composition, enantiomeric distribution and the biological profile of Hedyosmum strigosum essential oil (EO). The antioxidant properties and anticholinesterase effect were measured by spectroscopic methods and antimicrobial potency assessed against 8 bacteria and two fungi. H. strigosum is a native shrub, particularly found in Ecuador and Colombia at 2000 to 3500 m a.s.l. Chemical composition was determined by GC-MS and GC-FID. A total of 44 compounds were detected, representing more than 92% of the EO composition. The main compounds were thymol (24.35, 22.48%), alpha-phellandrene (12.15, 13.93%), thymol acetate (6.59, 9.39%) and linalool (8.73, 5.82%), accounting for more than 51% of the EO. The enantioselective analysis revealed the presence of 5 pure enantiomers and 3 more as a racemic mixture. The EO exerted a strong antioxidant capacity, determined by ABTS assay, with a SC(50) of 25.53 microg/mL and a strong and specific antimicrobial effect against Campylobacter jejuni with a MIC value of 125 microg/mL. A moderate acetylcholinesterase inhibitory effect was also observed with an IC(50) value of 137.6 microg/mL. To the best of our knowledge this is the first report of the chemical composition and biological profile of H. strigosum EO.