Carvalho_2005_Gene_359_91

Reference

Title : The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation - Carvalho_2005_Gene_359_91
Author(s) : Carvalho R , Reid R , Viswanathan N , Gramajo H , Julien B
Ref : Gene , 359 :91 , 2005
Abstract :

Disorazoles are polyketides produced by the myxobacterium Sorangium cellulosum So ce12. Their mode of action is to inhibit tubulin polymerization and destabilize microtubules. Using transposon mutagenesis, two mutant strains were identified that produced no disorazoles. Sequencing the DNA flanking the insertions revealed a polyketide synthase gene cluster that would encode three polypeptides, DszA, DszB, and DszC, with DszC containing both nonribosomal peptide synthetase and polyketide synthase modules. The disorazole polyketide synthase modules lack an acyltransferase domain. Instead, a separate gene, dszD, encodes an AT protein, thus revealing that the disorazole gene cluster falls into the trans-AT Type I family of PKS enzymes.

PubMedSearch : Carvalho_2005_Gene_359_91
PubMedID: 16084035
Gene_locus related to this paper: sorce-q4u445

Related information

Gene_locus sorce-q4u445

Citations formats

Carvalho R, Reid R, Viswanathan N, Gramajo H, Julien B (2005)
The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation
Gene 359 :91

Carvalho R, Reid R, Viswanathan N, Gramajo H, Julien B (2005)
Gene 359 :91