| Title : Brief-lifetime, fast-inactivating ion channels account for the alpha-bungarotoxin-sensitive nicotinic response in hippocampal neurons - Castro_1993_Neurosci.Lett_164_137 |
| Author(s) : Castro NG , Albuquerque EX |
| Ref : Neuroscience Letters , 164 :137 , 1993 |
|
Abstract :
Single-channel currents underlying the various types of nicotinic receptor-gated whole-cell currents (previously termed IA, IB, II and III) were identified in rat hippocampal neurons. In response to applied acetylcholine (ACh), most of the neurons showed a fast-decaying whole-cell current (type IA) that can be blocked by alpha-bungarotoxin (alpha-BGT). In these neurons, a novel nicotinic receptor channel was found, having a conductance of 73 pS and an open time of 0.12 ms at -80 mV. This channel showed a fast concentration-dependent inactivation that had a time constant of 0.5 ms at 1 mM ACh. A high Ca2+ permeability and the involvement of alpha 7 receptor subunits in the channel structure were suggested. |
| PubMedSearch : Castro_1993_Neurosci.Lett_164_137 |
| PubMedID: 7512242 |
Castro NG, Albuquerque EX (1993)
Brief-lifetime, fast-inactivating ion channels account for the alpha-bungarotoxin-sensitive nicotinic response in hippocampal neurons
Neuroscience Letters
164 :137
Castro NG, Albuquerque EX (1993)
Neuroscience Letters
164 :137