Ceppa_2002_Clin.Chem.Lab.Med_40_799

Reference

Title : Rapid identification of atypical variant of plasma butyrylcholinesterase by PCR - Ceppa_2002_Clin.Chem.Lab.Med_40_799
Author(s) : Ceppa F , Gidenne S , Benois A , Fontan E , Burnat P
Ref : Clinical Chemistry & Laboratory Medicine , 40 :799 , 2002
Abstract :

Human butyrylcholinesterase is the enzyme responsible of mivacurium and succinylcholine metabolism, which may be significantly impaired when mutation Asp70Gly is found in patients. We describe a simple PCR method for the detection of this variant. Thirteen out of sixteen patients tested after prolonged apnea were positive for the presence of this mutation (50.0% homozygotes and 31.3% heterozygotes), suggesting that this test contributes to the explanation of some clinical events and to their prevention in relatives of these patients.

PubMedSearch : Ceppa_2002_Clin.Chem.Lab.Med_40_799
PubMedID: 12392308

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Citations formats

Ceppa F, Gidenne S, Benois A, Fontan E, Burnat P (2002)
Rapid identification of atypical variant of plasma butyrylcholinesterase by PCR
Clinical Chemistry & Laboratory Medicine 40 :799

Ceppa F, Gidenne S, Benois A, Fontan E, Burnat P (2002)
Clinical Chemistry & Laboratory Medicine 40 :799