Chabrier_1980_Arch.Toxicol_45_15

Reference

Title : In vivo and in vitro inhibition of cholinesterase by methyl-1 (S methyl phosphoryl-3) imidazolium (MSPI), a model of an instantly aged phosphorylated enzyme - Chabrier_1980_Arch.Toxicol_45_15
Author(s) : Chabrier PE , Jacob J
Ref : Archives of Toxicology , 45 :15 , 1980
Abstract :

Methyl-1 (S-methylphosphoryl-3) imidazolium (MSPI) was approximately equipotent with DFP in producing in mice a lethal intoxication and in inhibiting in vitro cholinesterases of electric-eel, brain and plasma mice. In vivo, a lethal dose of MSPI inhibited plasma but not brain ChE. The intoxication by MSPI was not cured by the combination of Atropine and TMB4 or of diazepam with Atropine and (or) TMB4 and the cholinesterase inhibition was not reversed by TMB4 in vivo nor in vitro in the conditions where DPF intoxication or Che inhibition were.

PubMedSearch : Chabrier_1980_Arch.Toxicol_45_15
PubMedID: 7396718

Related information

Inhibitor MSPI

Citations formats

Chabrier PE, Jacob J (1980)
In vivo and in vitro inhibition of cholinesterase by methyl-1 (S methyl phosphoryl-3) imidazolium (MSPI), a model of an instantly aged phosphorylated enzyme
Archives of Toxicology 45 :15

Chabrier PE, Jacob J (1980)
Archives of Toxicology 45 :15