| Title : Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols - Chang_2003_Chem.Commun.(Camb)__960 |
| Author(s) : Chang D , Wang Z , Heringa MF , Wirthner R , Witholt B , Li Z |
| Ref : Chem Commun (Camb) , :960 , 2003 |
|
Abstract :
Hydrolysis of N-benzyloxycarbonyl-3,4-epoxy-pyrrolidine and cyclohexene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200, respectively, gave the corresponding vicinal trans-diols in high ee and yield, representing the first example of enantioselective hydrolysis of a meso-epoxide with a bacterial epoxide hydrolase. |
| PubMedSearch : Chang_2003_Chem.Commun.(Camb)__960 |
| PubMedID: 12744319 |
| Gene_locus related to this paper: 9sphn-a0a191xv39 |
| Substrate | 1-Cbz-pyrrolidine Cyclohexene-oxide |
| Gene_locus | 9sphn-a0a191xv39 |
Chang D, Wang Z, Heringa MF, Wirthner R, Witholt B, Li Z (2003)
Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols
Chem Commun (Camb)
:960
Chang D, Wang Z, Heringa MF, Wirthner R, Witholt B, Li Z (2003)
Chem Commun (Camb)
:960