| Title : Stereochemical insights into structurally diverse lignanamides from the herbs of Solanum lyratum Thunb - Chang_2023_Phytochemistry_215_113857 |
| Author(s) : Chang Y , Bai M , Zhang X , Hou JY , Chu CY , Niu JQ , Yao GD , Lin B , Huang XX , Song SJ |
| Ref : Phytochemistry , 215 :113857 , 2023 |
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Abstract :
A chemical investigation of Solanum lyratum Thunb. (Solanaceae) afforded six pairs of enantiomeric lignanamides consisting of twelve undescribed compounds, along with two undescribed racemic mixtures, and the separations of the enantiomers were accomplished by chiral-phase HPLC. The structures of these undescribed compounds were elucidated by the analysis of spectroscopic data, NMR and electronic circular dichroism calculations. All isolated compounds were assessed for neuroprotective activities in H(2)O(2)-induced human neuroblastoma SH-SY5Y cells, and acetylcholinesterase (AChE) inhibitory activities. Among tested isolates, some enantiomeric lignanamides exhibited conspicuous neuroprotective effects and AChE inhibitory effect. |
| PubMedSearch : Chang_2023_Phytochemistry_215_113857 |
| PubMedID: 37716545 |
Chang Y, Bai M, Zhang X, Hou JY, Chu CY, Niu JQ, Yao GD, Lin B, Huang XX, Song SJ (2023)
Stereochemical insights into structurally diverse lignanamides from the herbs of Solanum lyratum Thunb
Phytochemistry
215 :113857
Chang Y, Bai M, Zhang X, Hou JY, Chu CY, Niu JQ, Yao GD, Lin B, Huang XX, Song SJ (2023)
Phytochemistry
215 :113857