| Title : Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don - Changwichit_2011_Fitoterapia_82_798 |
| Author(s) : Changwichit K , Khorana N , Suwanborirux K , Waranuch N , Limpeanchob N , Wisuitiprot W , Suphrom N , Ingkaninan K |
| Ref : Fitoterapia , 82 :798 , 2011 |
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Abstract :
The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall. ex G. Don (Apocynaceae) showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay. Four compounds i.e., a bisindole alkaloid, macralstonine (1), a new bisindole alkaloid, thungfaine (2), a secoiridoid glycoside, sweroside (3) and a new secoiridoid glycoside, naresuanoside (4) were isolated. Compound 4 showed moderate AChE and butyrylcholinesterase (BChE) inhibitory effects. Interestingly, compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF). |
| PubMedSearch : Changwichit_2011_Fitoterapia_82_798 |
| PubMedID: 21601617 |
Changwichit K, Khorana N, Suwanborirux K, Waranuch N, Limpeanchob N, Wisuitiprot W, Suphrom N, Ingkaninan K (2011)
Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don
Fitoterapia
82 :798
Changwichit K, Khorana N, Suwanborirux K, Waranuch N, Limpeanchob N, Wisuitiprot W, Suphrom N, Ingkaninan K (2011)
Fitoterapia
82 :798