Chapla_2014_Molecules_19_19243

Reference

Title : Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca - Chapla_2014_Molecules_19_19243
Author(s) : Chapla VM , Zeraik ML , Leptokarydis IH , Silva GH , Bolzani VS , Young MC , Pfenning LH , Araujo AR
Ref : Molecules , 19 :19243 , 2014
Abstract :

In this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl)acetic acid (6), 4-hydroxy- benzamide (7) and 2(2-hydroxyphenyl)acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1-8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin.

PubMedSearch : Chapla_2014_Molecules_19_19243
PubMedID: 25421415

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Citations formats

Chapla VM, Zeraik ML, Leptokarydis IH, Silva GH, Bolzani VS, Young MC, Pfenning LH, Araujo AR (2014)
Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca
Molecules 19 :19243

Chapla VM, Zeraik ML, Leptokarydis IH, Silva GH, Bolzani VS, Young MC, Pfenning LH, Araujo AR (2014)
Molecules 19 :19243