| Title : Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis - Chapla_2014_Molecules_19_6597 |
| Author(s) : Chapla VM , Zeraik ML , Ximenes VF , Zanardi LM , Lopes MN , Cavalheiro AJ , Silva DH , Young MC , Fonseca LM , Bolzani VS , Araujo AR |
| Ref : Molecules , 19 :6597 , 2014 |
|
Abstract :
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro. |
| PubMedSearch : Chapla_2014_Molecules_19_6597 |
| PubMedID: 24858094 |
Chapla VM, Zeraik ML, Ximenes VF, Zanardi LM, Lopes MN, Cavalheiro AJ, Silva DH, Young MC, Fonseca LM, Bolzani VS, Araujo AR (2014)
Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
Molecules
19 :6597
Chapla VM, Zeraik ML, Ximenes VF, Zanardi LM, Lopes MN, Cavalheiro AJ, Silva DH, Young MC, Fonseca LM, Bolzani VS, Araujo AR (2014)
Molecules
19 :6597