| Title : Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7) - Chini_1994_Genomics_19_379 |
| Author(s) : Chini B , Raimond E , Elgoyhen AB , Moralli D , Balzaretti M , Heinemann S |
| Ref : Genomics , 19 :379 , 1994 |
|
Abstract :
We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha 7 neuronal nicotinic subunit (90%). We have mapped the human alpha 7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures. |
| PubMedSearch : Chini_1994_Genomics_19_379 |
| PubMedID: 8188270 |
Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S (1994)
Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)
Genomics
19 :379
Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S (1994)
Genomics
19 :379