Chiu_2005_Nucleic.Acids.Res_33_1690

Reference

Title : The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen - Chiu_2005_Nucleic.Acids.Res_33_1690
Author(s) : Chiu CH , Tang P , Chu C , Hu S , Bao Q , Yu J , Chou YY , Wang HS , Lee YS
Ref : Nucleic Acids Research , 33 :1690 , 2005
Abstract :

Salmonella enterica serovar Choleraesuis (S. Choleraesuis), a highly invasive serovar among non-typhoidal Salmonella, usually causes sepsis or extra-intestinal focal infections in humans. S. Choleraesuis infections have now become particularly difficult to treat because of the emergence of resistance to multiple antimicrobial agents. The 4.7 Mb genome sequence of a multidrug-resistant S. Choleraesuis strain SC-B67 was determined. Genome wide comparison of three sequenced Salmonella genomes revealed that more deletion events occurred in S. Choleraesuis SC-B67 and S.Typhi CT18 relative to S. Typhimurium LT2. S. Choleraesuis has 151 pseudogenes, which, among the three Salmonella genomes, include the highest percentage of pseudogenes arising from the genes involved in bacterial chemotaxis signal-transduction pathways. Mutations in these genes may increase smooth swimming of the bacteria, potentially allowing more effective interactions with and invasion of host cells to occur. A key regulatory gene of TetR/AcrR family, acrR, was inactivated through the introduction of an internal stop codon resulting in overexpression of AcrAB that appears to be associated with ciprofloxacin resistance. While lateral gene transfer providing basic functions to allow niche expansion in the host and environment is maintained during the evolution of different serovars of Salmonella, genes providing little overall selective benefit may be lost rapidly. Our findings suggest that the formation of pseudogenes may provide a simple evolutionary pathway that complements gene acquisition to enhance virulence and antimicrobial resistance in S. Choleraesuis.

PubMedSearch : Chiu_2005_Nucleic.Acids.Res_33_1690
PubMedID: 15781495
Gene_locus related to this paper: salen-OPDB , salti-q8z717 , salty-a1yjl0 , salty-AES , salty-BIOH , salty-DLHH , salty-ENTF , salty-FES , salty-IROD , salty-P74847 , salty-PLDB , salty-STM0332 , salty-STM2547 , salty-STM4506 , salty-yafa , salty-YBFF , salty-ycfp , salty-YFBB , salty-YHET , salty-YQIA

Related information

Gene_locus salen-OPDB    salti-q8z717    salty-a1yjl0    salty-AES    salty-BIOH    salty-DLHH    salty-ENTF    salty-FES    salty-IROD    salty-P74847    salty-PLDB    salty-STM0332    salty-STM2547    salty-STM4506    salty-yafa    salty-YBFF    salty-ycfp    salty-YFBB    salty-YHET    salty-YQIA
Gene_locus_frgt salch-q57hi6

Citations formats

Chiu CH, Tang P, Chu C, Hu S, Bao Q, Yu J, Chou YY, Wang HS, Lee YS (2005)
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen
Nucleic Acids Research 33 :1690

Chiu CH, Tang P, Chu C, Hu S, Bao Q, Yu J, Chou YY, Wang HS, Lee YS (2005)
Nucleic Acids Research 33 :1690