| Title : 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L - Cho_2006_Biol.Pharm.Bull_29_2317 |
| Author(s) : Cho KM , Yoo ID , Kim WG |
| Ref : Biol Pharm Bull , 29 :2317 , 2006 |
|
Abstract :
Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (microM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE. |
| PubMedSearch : Cho_2006_Biol.Pharm.Bull_29_2317 |
| PubMedID: 17077538 |
| Inhibitor | Chelerythrine 8-Hydroxydihydrochelerythrine |
Cho KM, Yoo ID, Kim WG (2006)
8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L
Biol Pharm Bull
29 :2317
Cho KM, Yoo ID, Kim WG (2006)
Biol Pharm Bull
29 :2317