Cho_2024_ACS.Appl.Mater.Interfaces__

Reference

Title : On-Site Formation of Functional Dopaminergic Presynaptic Terminals on Neuroligin-2-Modified Gold-Coated Microspheres - Cho_2024_ACS.Appl.Mater.Interfaces__
Author(s) : Cho W , Jung M , Yoon SH , Jeon J , Oh MA , Kim JY , Park M , Kang CM , Chung TD
Ref : ACS Appl Mater Interfaces , : , 2024
Abstract :

Advancements in neural interface technologies have enabled the direct connection of neurons and electronics, facilitating chemical communication between neural systems and external devices. One promising approach is a synaptogenesis-involving method, which offers an opportunity for synaptic signaling between these systems. Janus synapses, one type of synaptic interface utilizing synaptic cell adhesion molecules for interface construction, possess unique features that enable the determination of location, direction of signal flow, and types of neurotransmitters involved, promoting directional and multifaceted communication. This study presents the first successful establishment of a Janus synapse between dopaminergic (DA) neurons and abiotic substrates by using a neuroligin-2 (NLG2)-mediated synapse-inducing method. NLG2 immobilized on gold-coated microspheres can induce synaptogenesis upon contact with spatially isolated DA axons. The induced DA Janus synapses exhibit stable synaptic activities comparable to that of native synapses over time, suggesting their suitability for application in neural interfaces. By calling for DA presynaptic organizations, the NLG2-immobilized abiotic substrate is a promising tool for the on-site detection of synaptic dopamine release.

PubMedSearch : Cho_2024_ACS.Appl.Mater.Interfaces__
PubMedID: 38206769

Related information

Citations formats

Cho W, Jung M, Yoon SH, Jeon J, Oh MA, Kim JY, Park M, Kang CM, Chung TD (2024)
On-Site Formation of Functional Dopaminergic Presynaptic Terminals on Neuroligin-2-Modified Gold-Coated Microspheres
ACS Appl Mater Interfaces :

Cho W, Jung M, Yoon SH, Jeon J, Oh MA, Kim JY, Park M, Kang CM, Chung TD (2024)
ACS Appl Mater Interfaces :