| Title : Microbial transformation of (-)-isolongifolol and butyrylcholinesterase inhibitory activity of transformed products - Choudhary_2005_Bioorg.Med.Chem_13_1939 |
| Author(s) : Choudhary MI , Musharraf SG , Nawaz SA , Anjum S , Parvez M , Fun HK , Atta ur R |
| Ref : Bioorganic & Medicinal Chemistry , 13 :1939 , 2005 |
|
Abstract :
The microbial transformation of (-)-isolongifolol (1) by using the standard two-stage fermentation technique with Fusarium lini afforded polar oxygenated metabolites: 10-oxoisolongifolol (2), 10alpha-hydroxyisolongifolol (3), and 9alpha-hydroxyisolongifolol (4). Metabolites 3 and 4 were also formed with the incubation of 1 with Aspergillus niger. All three metabolites were found to be new. Compounds 3 and 4 inhibited butyrylcholinesterase enzyme in a concentration-dependent manner with IC50 values 13.6 and 299.5 microM, respectively. Compound 3 showed un-competitive mode of inhibition against butyrylcholinesterase with Ki value 15.0 microM. The structures of metabolites 2-4 were deduced on the basis of spectroscopic techniques and single-crystal X-ray diffraction techniques. |
| PubMedSearch : Choudhary_2005_Bioorg.Med.Chem_13_1939 |
| PubMedID: 15830442 |
Choudhary MI, Musharraf SG, Nawaz SA, Anjum S, Parvez M, Fun HK, Atta ur R (2005)
Microbial transformation of (-)-isolongifolol and butyrylcholinesterase inhibitory activity of transformed products
Bioorganic & Medicinal Chemistry
13 :1939
Choudhary MI, Musharraf SG, Nawaz SA, Anjum S, Parvez M, Fun HK, Atta ur R (2005)
Bioorganic & Medicinal Chemistry
13 :1939