| Title : Guaiane-type sesquiterpenoids with acetylcholinesterase inhibitory activities from the roots of Stellera chamaejasme - Chu_2026_Phytochemistry__114843 |
| Author(s) : Chu CY , Liu X , Mi SH , Bai M , Huang XX , Song SJ |
| Ref : Phytochemistry , :114843 , 2026 |
|
Abstract :
Phytochemical investigation on the roots of Stellera chamaejasme Linn. led to the isolation of twelve undescribed guaiane-type sesquiterpenoids (1-12). Their chemical structures were determined by a comprehensive analysis of spectroscopic data. The absolute configuration was elucidated by comparing experimental ECD. The acetylcholinesterase (AChE) inhibitory activities of isolated compounds were evaluated. Among these, compounds 3 and 9 exhibited comparable inhibitory activity, with IC(50) values of 2.81 +/- 0.37 microM and 3.22 +/- 0.21 microM, even more than Donepezil. Additionally, the molecular modeling studies revealed the structural basis for the significant inhibitory activity of compounds 3 and 9. |
| PubMedSearch : Chu_2026_Phytochemistry__114843 |
| PubMedID: 41780736 |
Chu CY, Liu X, Mi SH, Bai M, Huang XX, Song SJ (2026)
Guaiane-type sesquiterpenoids with acetylcholinesterase inhibitory activities from the roots of Stellera chamaejasme
Phytochemistry
:114843
Chu CY, Liu X, Mi SH, Bai M, Huang XX, Song SJ (2026)
Phytochemistry
:114843