Chuong_2014_Molecules_19_19172

Reference

Title : Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis - Chuong_2014_Molecules_19_19172
Author(s) : Chuong NN , Huong NT , Hung TM , Luan TC
Ref : Molecules , 19 :19172 , 2014
Abstract :

A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8alpha-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 mug/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 microg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.

PubMedSearch : Chuong_2014_Molecules_19_19172
PubMedID: 25415478

Related information

Citations formats

Chuong NN, Huong NT, Hung TM, Luan TC (2014)
Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis
Molecules 19 :19172

Chuong NN, Huong NT, Hung TM, Luan TC (2014)
Molecules 19 :19172