| Title : Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells - Ciruela_1997_FEBS.Lett_418_83 |
| Author(s) : Ciruela F , McIlhinney RA |
| Ref : FEBS Letters , 418 :83 , 1997 |
|
Abstract :
The internalisation of metabotropic glutamate receptor (mGluR1alpha) and its splice variant (mGluR1beta), in response to agonist and phorbol esters (PMA), has been studied. Both mGluR1alpha and mGluR1beta exhibit a similar rate of internalisation following PMA treatment, with a shift in their distribution from plasma membrane to endosome-enriched membrane fractions. Agonist challenge however caused a rapid loss, within 5-10 min, of mGluR1beta but not mGluR1alpha from the cell surface. These results show that the two forms of mGluR1 show different internalisation responses to agonist and suggest that the C-terminal region of the molecule plays an important role in this phenomenon. |
| PubMedSearch : Ciruela_1997_FEBS.Lett_418_83 |
| PubMedID: 9414100 |
Ciruela F, McIlhinney RA (1997)
Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells
FEBS Letters
418 :83
Ciruela F, McIlhinney RA (1997)
FEBS Letters
418 :83