| Title : Cell surface expression of the metabotropic glutamate receptor type 1alpha is regulated by the C-terminal tail - Ciruela_1999_FEBS.Lett_448_91 |
| Author(s) : Ciruela F , Soloviev MM , McIlhinney RA |
| Ref : FEBS Letters , 448 :91 , 1999 |
|
Abstract :
The cell surface expression of metabotropic glutamate receptor type I splice variants has been studied using cell surface biotinylation. Co-expression of the last 86 residues of the C-terminal tail of mGluR1alpha (F2-protein) with mGluR1alpha caused a significant reduction of the amount of the cell surface receptor when compared to that in cells transfected with mGlur1alpha alone, and this was accompanied by a reduction in the production of inositol following agonist stimulation of the cells. In contrast, cell surface expression of mGluR1beta was unaltered by co-expression with the F2-protein. These results suggest that the C-terminal tail of mGluR1alpha regulates cell surface expression of the receptor. |
| PubMedSearch : Ciruela_1999_FEBS.Lett_448_91 |
| PubMedID: 10217416 |
Ciruela F, Soloviev MM, McIlhinney RA (1999)
Cell surface expression of the metabotropic glutamate receptor type 1alpha is regulated by the C-terminal tail
FEBS Letters
448 :91
Ciruela F, Soloviev MM, McIlhinney RA (1999)
FEBS Letters
448 :91