| Title : Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block - Clark_2002_Bioorg.Med.Chem.Lett_12_2565 |
| Author(s) : Clark JK , Cowley P , Muir AW , Palin R , Pow E , Prosser AB , Taylor R , Zhang MQ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :2565 , 2002 |
|
Abstract :
A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. Several potent reversal agents have been identified and their haemodynamic effects measured. |
| PubMedSearch : Clark_2002_Bioorg.Med.Chem.Lett_12_2565 |
| PubMedID: 12182861 |
Clark JK, Cowley P, Muir AW, Palin R, Pow E, Prosser AB, Taylor R, Zhang MQ (2002)
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block
Bioorganic & Medicinal Chemistry Lett
12 :2565
Clark JK, Cowley P, Muir AW, Palin R, Pow E, Prosser AB, Taylor R, Zhang MQ (2002)
Bioorganic & Medicinal Chemistry Lett
12 :2565