| Title : In vitro and in vivo evidence for the existence of presynaptic muscarinic cholinergic receptors in the rat hippocampus - Consolo_1984_Brain.Res_309_147 |
| Author(s) : Consolo S , Wang JX , Fusi R , Vinci R , Forloni G , Ladinsky H |
| Ref : Brain Research , 309 :147 , 1984 |
|
Abstract :
The intrahippocampal injection of kainic acid cleared 50% of muscarinic receptors and favored the detection of a further 20% loss in hippocampal presynaptic muscarinic receptors produced by electrolytic lesion of the medial septal nucleus as determined by Scatchard analysis of the saturation isotherms of [3H]dexetimide binding. In accordance, a decrease of about 20% in the in vivo accumulation of [3H]dexetimide in the hippocampus was found in animals lesioned in the medial septal nucleus. This effect occurred at both the dose of 5 micrograms/kg and at the saturating dose of 100 micrograms/kg of [3H]dexetimide. The results suggest that the loss was due to decreased receptor number rather than decreased receptor affinity. |
| PubMedSearch : Consolo_1984_Brain.Res_309_147 |
| PubMedID: 6488003 |
Consolo S, Wang JX, Fusi R, Vinci R, Forloni G, Ladinsky H (1984)
In vitro and in vivo evidence for the existence of presynaptic muscarinic cholinergic receptors in the rat hippocampus
Brain Research
309 :147
Consolo S, Wang JX, Fusi R, Vinci R, Forloni G, Ladinsky H (1984)
Brain Research
309 :147