| Title : Cimetidine does not inhibit plasma cholinesterase activity - Cook_1988_Anesth.Analg_67_375 |
| Author(s) : Cook DR , Stiller RL , Chakravorti S , Mannenhira T |
| Ref : Anesthesia & Analgesia , 67 :375 , 1988 |
|
Abstract :
Cimetidine increases the duration of action of succinylcholine several-fold by an unknown mechanism. The hydrolysis rate of succinylcholine by human plasma was measured with a modified spectrophotometric assay. At a concentration of 1-50 micrograms/ml cimetidine did not inhibit the hydrolysis of succinylcholine. It is concluded that cimetidine may have an effect at the neuromuscular junction but does not inhibit plasma cholinesterase. |
| PubMedSearch : Cook_1988_Anesth.Analg_67_375 |
| PubMedID: 3354873 |
Cook DR, Stiller RL, Chakravorti S, Mannenhira T (1988)
Cimetidine does not inhibit plasma cholinesterase activity
Anesthesia & Analgesia
67 :375
Cook DR, Stiller RL, Chakravorti S, Mannenhira T (1988)
Anesthesia & Analgesia
67 :375