| Title : Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity - Cook_1988_Toxicon_26_750 |
| Author(s) : Cook WO , Beasley VR , Dahlem AM , Dellinger JA , Harlin KS , Carmichael WW |
| Ref : Toxicon , 26 :750 , 1988 |
|
Abstract :
Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood-brain barrier. |
| PubMedSearch : Cook_1988_Toxicon_26_750 |
| PubMedID: 3188065 |
| Inhibitor | Guanitoxin Pyridostigmine |
Cook WO, Beasley VR, Dahlem AM, Dellinger JA, Harlin KS, Carmichael WW (1988)
Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity
Toxicon
26 :750
Cook WO, Beasley VR, Dahlem AM, Dellinger JA, Harlin KS, Carmichael WW (1988)
Toxicon
26 :750