| Title : Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation - Corey_2023_Cell.Chem.Biol_30_1004 |
| Author(s) : Corey Z , Schechter E , Nemenoff RA |
| Ref : Cell Chemical Biology , 30 :1004 , 2023 |
|
Abstract :
MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al.(1) report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy. |
| PubMedSearch : Corey_2023_Cell.Chem.Biol_30_1004 |
| PubMedID: 37738950 |
Corey Z, Schechter E, Nemenoff RA (2023)
Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation
Cell Chemical Biology
30 :1004
Corey Z, Schechter E, Nemenoff RA (2023)
Cell Chemical Biology
30 :1004