| Title : Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor - Cotecchia_1988_Proc.Natl.Acad.Sci.U.S.A_85_7159 |
| Author(s) : Cotecchia S , Schwinn DA , Randall RR , Lefkowitz RJ , Caron MG , Kobilka BK |
| Ref : Proc Natl Acad Sci U S A , 85 :7159 , 1988 |
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Abstract :
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism. |
| PubMedSearch : Cotecchia_1988_Proc.Natl.Acad.Sci.U.S.A_85_7159 |
| PubMedID: 2845398 |
Cotecchia S, Schwinn DA, Randall RR, Lefkowitz RJ, Caron MG, Kobilka BK (1988)
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor
Proc Natl Acad Sci U S A
85 :7159
Cotecchia S, Schwinn DA, Randall RR, Lefkowitz RJ, Caron MG, Kobilka BK (1988)
Proc Natl Acad Sci U S A
85 :7159