Cousins_1994_Psychopharmacology.(Berl)_116_529

Reference

Title : Pharmacological characterization of performance on a concurrent lever pressing\/feeding choice procedure: effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs - Cousins_1994_Psychopharmacology.(Berl)_116_529
Author(s) : Cousins MS , Wei W , Salamone JD
Ref : Psychopharmacology (Berl) , 116 :529 , 1994
Abstract :

This experiment was undertaken to provide a pharmacological characterization of performance on a task involving food-related instrumental and consummatory behavior. Rats were tested in an operant chamber in which there was a choice between pressing a lever to receive a preferred food (Bioserve pellets) or approaching and consuming a less-preferred food (Lab Chow). The lever pressing schedule was a fixed ratio 5 (FR5). Rats usually pressed the lever at high rates to obtain the preferred food, and typically ate little of the lab chow even though it was freely available in the chamber concurrently with the lever pressing schedule. Previous work has shown that injection of dopamine (DA) antagonists, or depletion of DA in the nucleus accumbens, caused a substantial shift in behavior such that lever pressing was reduced but chow consumption increased. In the present study it was shown that the DA antagonist haloperidol decreased lever pressing and increased chow consumption at doses of 0.1 and 0.15 mg/kg. The D1 antagonist SCH 23390 (0.05, 0.1 and 0.15 mg/kg) and the non-selective DA antagonist cis-flupenthixol (0.3 and 0.45 mg/kg) decreased lever pressing and produced substantial increases in chow consumption. The D2 antagonist sulpiride decreased lever pressing, but produced only slight increases in chow intake at the highest dose. Pentobarbital reduced lever pressing and increased chow consumption at 10.0 mg/kg. The muscarinic agonist pilocarpine produced dose-related decreases in lever pressing, but failed to increase chow consumption. Amphetamine produced dose-related decreases in both lever pressing and chow consumption.(ABSTRACT TRUNCATED AT 250 WORDS)

PubMedSearch : Cousins_1994_Psychopharmacology.(Berl)_116_529
PubMedID: 7701059

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Citations formats

Cousins MS, Wei W, Salamone JD (1994)
Pharmacological characterization of performance on a concurrent lever pressing\/feeding choice procedure: effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs
Psychopharmacology (Berl) 116 :529

Cousins MS, Wei W, Salamone JD (1994)
Psychopharmacology (Berl) 116 :529