| Title : Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis - Cox_2004_Chem.Commun.(Camb)_2004_2260 |
| Author(s) : Cox RJ , Glod F , Hurley D , Lazarus CM , Nicholson TP , Rudd BA , Simpson TJ , Wilkinson B , Zhang Y |
| Ref : Chem Commun (Camb) , :2260 , 2004 |
|
Abstract :
PCR primers designed to selectively amplify the unique C-methyltransferase domain of fungal polyketide synthases were used to selectively clone a polyketide synthase gene involved in the biosynthesis of the squalene synthase inhibitor squalestatin S1 , heterologous expression of which led to the biosynthesis of the squalestatin side-chain. |
| PubMedSearch : Cox_2004_Chem.Commun.(Camb)_2004_2260 |
| PubMedID: 15489970 |
| Gene_locus related to this paper: phosm-mfm8 |
| Gene_locus | phosm-mfm8 |
Cox RJ, Glod F, Hurley D, Lazarus CM, Nicholson TP, Rudd BA, Simpson TJ, Wilkinson B, Zhang Y (2004)
Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis
Chem Commun (Camb)
:2260
Cox RJ, Glod F, Hurley D, Lazarus CM, Nicholson TP, Rudd BA, Simpson TJ, Wilkinson B, Zhang Y (2004)
Chem Commun (Camb)
:2260