| Title : The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community- based populations - Crawford_1998_Neurosci.Lett_249_115 |
| Author(s) : Crawford F , Fallin D , Suo Z , Abdullah L , Gold M , Gauntlett A , Duara R , Mullan M |
| Ref : Neuroscience Letters , 249 :115 , 1998 |
|
Abstract :
The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the epsilon4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an increased risk of late-onset AD. We have genotyped 62 community-based and 329 clinic-based AD cases, and 201 community-based controls at BChE and APOE and find no independent association between BChE and AD nor interaction with APOE in risk for AD in either our clinic or community-based samples. |
| PubMedSearch : Crawford_1998_Neurosci.Lett_249_115 |
| PubMedID: 9682830 |
Crawford F, Fallin D, Suo Z, Abdullah L, Gold M, Gauntlett A, Duara R, Mullan M (1998)
The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community- based populations
Neuroscience Letters
249 :115
Crawford F, Fallin D, Suo Z, Abdullah L, Gold M, Gauntlett A, Duara R, Mullan M (1998)
Neuroscience Letters
249 :115