| Title : Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors - Cristalli_2005_J.Med.Chem_48_2763 |
| Author(s) : Cristalli G , Podda GM , Costanzi S , Lambertucci C , Lecchi A , Vittori S , Volpini R , Zighetti ML , Cattaneo M |
| Ref : Journal of Medicinal Chemistry , 48 :2763 , 2005 |
|
Abstract :
Newly synthesized mono-, di-, and triphosphate of 2-alkynyl adenosines showed very different behavior in human platelet P2Y receptor models, according to the different alkynyl chains. In fact, 2-hexynyladenosine di- (5) and triphosphate (7) induced platelet shape change and aggregation and inhibited PGE(1)-induced increase in platelet cyclic AMP. On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP. |
| PubMedSearch : Cristalli_2005_J.Med.Chem_48_2763 |
| PubMedID: 15828813 |
Cristalli G, Podda GM, Costanzi S, Lambertucci C, Lecchi A, Vittori S, Volpini R, Zighetti ML, Cattaneo M (2005)
Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors
Journal of Medicinal Chemistry
48 :2763
Cristalli G, Podda GM, Costanzi S, Lambertucci C, Lecchi A, Vittori S, Volpini R, Zighetti ML, Cattaneo M (2005)
Journal of Medicinal Chemistry
48 :2763