| Title : Identification of procyanidins as alpha-glucosidase inhibitors, pancreatic lipase inhibitors, and antioxidants from the bark of Cinnamomum cassia by multi-bioactivity-labeled molecular networking - Dai_2024_Food.Res.Int_192_114833 |
| Author(s) : Dai J , Liu Z , Ma L , Yang C , Bai L , Han D , Song Q , Yan H , Wang Z |
| Ref : Food Res Int , 192 :114833 , 2024 |
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Abstract :
This study examined the suppressive effects of 16 selected plant-based foods on alpha-glucosidase and pancreatic lipase and their antioxidant properties. Among these, the bark of Cinnamomum cassia (Cinnamon, WLN-FM 15) showed the highest inhibitory activity against alpha-glucosidase and the highest antioxidant activity. Additionally, WLN-FM 15 showed promising results in the other tests. To further identify the bioactive constituents of WLN-FM 15, a multi-bioactivity-labeled molecular networking approach was used through a combination of GNPS-based molecular networking, DPPH-HPLC, and affinity-based ultrafiltration-HPLC. A total of nine procyanidins were identified as antioxidants and inhibitors of alpha-glucosidase and pancreatic lipase in WLN-FM 15. Subsequently, procyanidins A1, A2, B1, and C1 were isolated, and their efficacy was confirmed through functional assays. In summary, WLN-FM 15 has the potential to serve as a functional food ingredient with the procyanidins as its bioactive constituents. These results also suggest that the multi-bioactivity-labeled molecular networking approach is reliable for identifying bioactive constituents in plant-based foods. |
| PubMedSearch : Dai_2024_Food.Res.Int_192_114833 |
| PubMedID: 39147522 |
Dai J, Liu Z, Ma L, Yang C, Bai L, Han D, Song Q, Yan H, Wang Z (2024)
Identification of procyanidins as alpha-glucosidase inhibitors, pancreatic lipase inhibitors, and antioxidants from the bark of Cinnamomum cassia by multi-bioactivity-labeled molecular networking
Food Res Int
192 :114833
Dai J, Liu Z, Ma L, Yang C, Bai L, Han D, Song Q, Yan H, Wang Z (2024)
Food Res Int
192 :114833