Title : Studies on the cholinesterases inhibiting compounds from the Cassiopea andromeda venom - Darabi_2020_Bioinformation_16_702 |
Author(s) : Darabi AH , Nabipour I , Mohebbi G , Vazirizadeh A , Vatanpour H , Maryamabadi A |
Ref : Bioinformation , 16 :702 , 2020 |
Abstract :
Cholinesterase inhibitors find application in the combat and care of several diseases, especially AD. Jellyfish venoms are the most promising sources of potent cholinesterase inhibitors. Therefore, it is of interest to study cholinesterases inhibiting compounds from the Cassiopea andromeda venom. We report bioactive compounds using the GC-MC method followed by molecular modeling and docking data analysis. The GC-MS analysis of the crude venom led to the identification of seven bioactive compounds (C1-C7), comprising the steroidal alkaloids, phenolic and carotenoid derivatives. The venom exhibited inhibitory activities against the cholinesterase enzymes. The compound C2, a Dioxolane steroid, displayed the strongest inhibition on both AChE and BChE activities for further consideration. |
PubMedSearch : Darabi_2020_Bioinformation_16_702 |
PubMedID: 34621116 |
Darabi AH, Nabipour I, Mohebbi G, Vazirizadeh A, Vatanpour H, Maryamabadi A (2020)
Studies on the cholinesterases inhibiting compounds from the Cassiopea andromeda venom
Bioinformation
16 :702
Darabi AH, Nabipour I, Mohebbi G, Vazirizadeh A, Vatanpour H, Maryamabadi A (2020)
Bioinformation
16 :702