| Title : Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes - Dascal_1985_Proc.Natl.Acad.Sci.U.S.A_82_6001 |
| Author(s) : Dascal N , Lotan I , Gillo B , Lester HA , Lass Y |
| Ref : Proc Natl Acad Sci U S A , 82 :6001 , 1985 |
|
Abstract :
In Xenopus laevis oocytes, adenosine and other purinergic agonists induce a K+-conductance increase that is fully mimicked by intracellular application of cAMP. Acetylcholine suppresses the K+-conductance increase caused by adenosine, by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, or by intracellular injection of cAMP. This effect of acetylcholine is not mimicked by intracellular injection of Ca2+ or of the Ca-mobilizing agent inositol 1,4,5-trisphosphate. However, adenosine and cAMP responses are inhibited by 4 beta-phorbol 12,13-dibutyrate and 4 beta-phorbol 12-myristate 13-acetate. These results suggest that, in Xenopus oocytes, the muscarinic inhibition of purinergic and cAMP responses is mediated through the activation of the phospholipid-dependent, Ca-activated protein kinase (protein kinase C). |
| PubMedSearch : Dascal_1985_Proc.Natl.Acad.Sci.U.S.A_82_6001 |
| PubMedID: 2994058 |
Dascal N, Lotan I, Gillo B, Lester HA, Lass Y (1985)
Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes
Proc Natl Acad Sci U S A
82 :6001
Dascal N, Lotan I, Gillo B, Lester HA, Lass Y (1985)
Proc Natl Acad Sci U S A
82 :6001