Title : Lymphocytic enzymes and lipid peroxidation in patients with metabolic syndrome - De Bona_2012_Clin.Biochem_45_1081 |
Author(s) : De Bona KS , Bonfanti G , Cargnelutti LO , Bitencourt PE , da Silva PS , Ceolin R , Pimentel VC , Moretto MB |
Ref : Clinical Biochemistry , 45 :1081 , 2012 |
Abstract :
OBJECTIVES Metabolic syndrome MetS is considered a state of chronic inflammation This study aimed to ascertain selected parameters of purinergic and cholinergic systems related to glucose metabolism and inflammation as well as gamma)-glutamyltransferase GGT and N-acetyl-b-glucosaminidase NAG activities and lipoperoxidation in lymphocytes of patients with MetS DESIGN AND METHODS The adenosine deaminase ADA dipeptidyl peptidase IV DPP-IV acetylcholinesterase AChE GGT and NAG activities as well as thiobarbituric acid reactive substances TBARS levels were investigated in lymphocytes of patients with MetS n=38 and healthy volunteers n=41 We also evaluated the insulin levels anthropometric measurements and routine biochemical analyses RESULTS ADA p<0.05 DPP-IV and AChE p<0.0001 activities were higher in patients with MetS when compared to the control group Furthermore we observed correlations between ADA and DPP-IV activities p=0.0002 r=0.5945 TBARS levels and ADA p=0.0021 r=0.5172 and DPP-IV activities p=0.0022 r=0.5010 CONCLUSIONS Our findings showed that MetS might cause tissue distress that disturbed lymphocytic ADA DPP-IV and AChE activities in response to inflammatory stimuli These alterations evidence clinical abnormalities since these enzymatic systems are able to regulate several aspects of adipose tissue function and inflammatory state of MetS and could be used successfully both for preventing and for halting the progression of MetS. |
PubMedSearch : De Bona_2012_Clin.Biochem_45_1081 |
PubMedID: 22709933 |
De Bona KS, Bonfanti G, Cargnelutti LO, Bitencourt PE, da Silva PS, Ceolin R, Pimentel VC, Moretto MB (2012)
Lymphocytic enzymes and lipid peroxidation in patients with metabolic syndrome
Clinical Biochemistry
45 :1081
De Bona KS, Bonfanti G, Cargnelutti LO, Bitencourt PE, da Silva PS, Ceolin R, Pimentel VC, Moretto MB (2012)
Clinical Biochemistry
45 :1081