| Title : Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET - De Vos_2000_Nucl.Med.Biol_27_745 |
| Author(s) : De Vos F , Santens P , Vermeirsch H , Dewolf I , Dumont F , Slegers G , Dierckx RA , De Reuck J |
| Ref : Nucl Med Biol , 27 :745 , 2000 |
|
Abstract :
Donepezil is a highly potent and selective reversible achetylcholinesterase inhibitor. [(11)C]Donepezil is prepared by methylation with [(11)C]CH(3)I of the corresponding 6'-O-desmethylprecursor. Tissue distribution in mice revealed a high uptake in brain and rapid clearance from the blood. Metabolization studies in mice indicated the formation of one (11)C-labeled polar metabolite that didn't penetrate the blood-brain barrier. Regional brain distribution in rabbits didn't reflect the measured achetylcholinesterase distribution in rabbit brain. |
| PubMedSearch : De Vos_2000_Nucl.Med.Biol_27_745 |
| PubMedID: 11150706 |
De Vos F, Santens P, Vermeirsch H, Dewolf I, Dumont F, Slegers G, Dierckx RA, De Reuck J (2000)
Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET
Nucl Med Biol
27 :745
De Vos F, Santens P, Vermeirsch H, Dewolf I, Dumont F, Slegers G, Dierckx RA, De Reuck J (2000)
Nucl Med Biol
27 :745