| Title : Regional localization of a beta-galactosidase locus on human chromosome 22 - De Wit_1977_Somatic.Cell.Genet_3_351 |
| Author(s) : De Wit J , Hoeksema HL , Halley D , Hagemeijer A , Bootsma D , Westerveld A |
| Ref : Somatic Cell Genet , 3 :351 , 1977 |
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Abstract :
Human white blood cells with an X/22 translocation [46, XX, t(X;22)(q23;q13)] were fused with Chinese hamster cells. The isolated hybrids were analyzed for human chromosomes and 21 enzyme markers. An electrophoretic technique for studying the beta-galactosidase isoenzymes in man-Chinese hamster hybrid cells was developed. Immunological studies showed that the beta-galactosidase marker studied in these hybrids did contain immunological determinants of human origin. Furthermore the results provided evidence that a locus for beta-galactosidase is situated on chromosome 22 distal to the breakpoint in q13. |
| PubMedSearch : De Wit_1977_Somatic.Cell.Genet_3_351 |
| PubMedID: 414365 |
| Gene_locus related to this paper: human-CTSA |
| Gene_locus | human-CTSA |
| Disease | Galactosialidosis |
De Wit J, Hoeksema HL, Halley D, Hagemeijer A, Bootsma D, Westerveld A (1977)
Regional localization of a beta-galactosidase locus on human chromosome 22
Somatic Cell Genet
3 :351
De Wit J, Hoeksema HL, Halley D, Hagemeijer A, Bootsma D, Westerveld A (1977)
Somatic Cell Genet
3 :351