| Title : TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo - Debeir_1998_J.Physiol.Paris_92_205 |
| Author(s) : Debeir T , Saragovi HU , Cuello AC |
| Ref : Journal de Physiologie (Paris) , 92 :205 , 1998 |
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Abstract :
Cholinergic neurons are known to respond in vivo to the administration of nerve growth factor (NGF) by a prominent and selective increase of choline acetyl transferase activity and by cholinergic synaptogenesis in the rat brain. By using a synthetic TrkA antagonist we demonstrated that endogenously produced NGF is involved in the continual re-modeling of cholinergic neuronal connections during adulthood, acting through TrkA receptors. |
| PubMedSearch : Debeir_1998_J.Physiol.Paris_92_205 |
| PubMedID: 9789809 |
Debeir T, Saragovi HU, Cuello AC (1998)
TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo
Journal de Physiologie (Paris)
92 :205
Debeir T, Saragovi HU, Cuello AC (1998)
Journal de Physiologie (Paris)
92 :205