| Title : Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase - Decker_2006_Bioorg.Med.Chem_14_1966 |
| Author(s) : Decker M , Krauth F , Lehmann J |
| Ref : Bioorganic & Medicinal Chemistry , 14 :1966 , 2006 |
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Abstract :
Tetracyclic nitrogen bridgehead compounds, dibenzodiazecines and tricyclic quinazolinimines, in which the size of the alicyclic ring system and the length of the alkyl chain between the quinazolinimine moiety and a phenyl ring connected to the imine nitrogen atom were changed systematically, were synthesized and their ability to inhibit acetyl- and butyrylcholinesterase (AChE/BChE), respectively, was evaluated. Moderate and strong inhibitors of BChE--compared to galanthamine and rivastigmine--were identified, which show mixed affinities or are moderately or highly selective towards BChE, respectively. |
| PubMedSearch : Decker_2006_Bioorg.Med.Chem_14_1966 |
| PubMedID: 16289855 |
Decker M, Krauth F, Lehmann J (2006)
Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase
Bioorganic & Medicinal Chemistry
14 :1966
Decker M, Krauth F, Lehmann J (2006)
Bioorganic & Medicinal Chemistry
14 :1966