| Title : Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin - Degen_1999_Bioorg.Med.Chem.Lett_9_973 |
| Author(s) : Degen SJ , Mueller KL , Shen HC , Mulder JA , Golding GM , Wei LL , Zificsak CA , Neeno-Eckwall A , Hsung RP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 9 :973 , 1999 |
|
Abstract :
A general approach to synthesis of dihydroxanthone derivatives is described here. In vitro evaluation of these dihydroxanthones demonstrated that some derivatives possess moderate anti-cholinesterase activities and better selectivities than tacrine for acetylcholinesterase over butyrylcholinesterase. Structural effects on anti-cholinesterase activities were also examined, and docking experiments were carried out to provide preliminary understandings of these experimental observations. |
| PubMedSearch : Degen_1999_Bioorg.Med.Chem.Lett_9_973 |
| PubMedID: 10230623 |
| Inhibitor | ArisugacinA ArisugacinB |
Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP (1999)
Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin
Bioorganic & Medicinal Chemistry Lett
9 :973
Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP (1999)
Bioorganic & Medicinal Chemistry Lett
9 :973