Dilshad_2015_Nat.Prod.Res__1

Reference

Title : New lipoxygenase and cholinesterase inhibitory sphingolipids from Carthamus oxyacantha - Dilshad_2015_Nat.Prod.Res__1
Author(s) : Dilshad M , Riaz N , Saleem M , Shafiq N , Ashraf M , Ismail T , Rafiq HM , Jabbar A
Ref : Nat Prod Res , :1 , 2015
Abstract :

Two new sphingolipids: oxyacanthin A [(2S,3S,4R)-2-{[(2R,5E)-2-hydroxyoctadec-5-enoyl]amino}hexaeicosane-1,3,4-triol; 1] and B [(2S,3S,4R)-2-{[(2R,5E)-2-hydroxyoctadec-5-enoyl]amino}hexaeicosane-1,3,4-triol-1 -O-beta-D-glucopyranoside; 2], together with 1-octacosanol, beta-sitosterol, beta-sitosterol 3-O-beta-D-glucopyranoside and luteolin 7-O-beta-glucopyranoside were isolated from the methanolic extract of the whole plant of Carthamus oxyacantha. Their structures were elucidated using 1H and 13C NMR spectra and 2D NMR analyses (HMQC, HMBC and COSY) in combination with mass spectrometry (EI-MS, HR-EI-MS, FAB-MS and HR-FAB-MS) experiments and in comparison with the literature data of the related compounds. Both the compounds 1 and 2 showed inhibitory potential against lipoxygenase (LOX) in a concentration-dependent manner with IC50 values 83.3 +/- 1.3 and 245.7 +/- 1.1 microM, whereas compound 2 showed inhibition against enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values 65.3 +/- 0.1 and 93.6 +/- 0.1 microM, respectively.

PubMedSearch : Dilshad_2015_Nat.Prod.Res__1
PubMedID: 26285908

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Citations formats

Dilshad M, Riaz N, Saleem M, Shafiq N, Ashraf M, Ismail T, Rafiq HM, Jabbar A (2015)
New lipoxygenase and cholinesterase inhibitory sphingolipids from Carthamus oxyacantha
Nat Prod Res :1

Dilshad M, Riaz N, Saleem M, Shafiq N, Ashraf M, Ismail T, Rafiq HM, Jabbar A (2015)
Nat Prod Res :1